Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging
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چکیده
منابع مشابه
Arginase Inhibition Reverses Monocrotaline-Induced Pulmonary Hypertension
Pulmonary hypertension (PH) is a heterogeneous disorder associated with a poor prognosis. Thus, the development of novel treatment strategies is of great interest. The enzyme arginase (Arg) is emerging as important player in PH development. The aim of the current study was to determine the expression of ArgI and ArgII as well as the effects of Arg inhibition in a rat model of PH. PH was induced...
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In the course of an attempt to develop a rapid method for the enzymatic determination of arginine it was observed that a quantity of arginase, which would hydrolyze 31 mg. of pure arginine in less than 1 hour, took much longer to achieve the same performance within a, protein hydrolysate, 4 hours in the case of arachin, 5 in that of gelatin, and even more in that of casein. The obvious inferenc...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2020
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2020.173442